3-Methoxy-2,2,3,3-tetrafluoromethyl propionate (MTPME) is colorless and clear liquid, with aroma, has inflammability, stable performance, relative non-toxicity, and easy to be decomposed at high temperature. It is an important fluoride industrial chemical, also used as solvent , and a key intermediate to produce perfluoro or partial fluorinated vinyl ester and PFCA resin. It is widely applied in production of adhesive, dye, pharmaceutical intermediate and fluoropolymers.