Chemical Name:Regorafenib
CAS No.: 755037-03-7
Molecular formula: C21H15ClF4N4O3
Molecular weight: 482.8154128
Nature
Melting point | 206.0 to 210.0 °C |
Synthetic route
Method 1:4-chloro-2-pyridine formamide hydrochloride was prepared from 2-pyridine formic acid by chlorination and amidation. Rigofini was prepared from 4-amino-3-fluorophenol and 4-chloro-3-trifluoromethyl benzene isocyanate in a pot. The specific reaction process was as follows:
Method 2:2 - piperidine formic acid as raw material, through chlorination, amidation, methanol solution by 4 - chloro - 2 - pyridine formamide, and amino - 4-3 - p -fluorophenol nucleophilic replace get 4 - (4 - amino - 3-3 methyl) - N - methyl pyridine - 2 - formamide, and again three fluorine chlorine - 4-3 - methyl phenyl isocyanate condensation Craig fini, get specific reaction process is as follows:
