Chemical Name:2,4,7-Triamino-6-phenylpteridine
CAS No.: 396-01-0
Molecular formula: C12H11N7
Molecular weight: 253.26
Related categories: DYRENIUM; Other APIs; pharmaceutical intermediates; small molecule inhibitors; pharmaceutical raw materials; diuretic bulk drugs
Nature
Melting point | 316°C |
Boiling point | 386.46°C (rough estimate) |
Density | 1.3215 (rough estimate) |
Refractive index | 1.8260 (estimate) |
Flash point | 11 °C |
Storage conditions | 2-8°C |
Solubility | formic acid: soluble200 mg + 4 mL warm Formic Acid, clear, yellow-green |
Acidity coefficient (pKa) | 6.2(at 25℃) |
Water solubility | <0.1 G/100 ML AT 20 oC |
Merck | 14,9599 |
BRN | 266723 |
InChIKey | FNYLWPVRPXGIIP-UHFFFAOYSA-N |
CAS database | 396-01-0(CAS DataBase Reference) |
Traits
It is a yellow crystalline powder, odorless or almost odorless and tasteless. Insoluble in water, ethanol, chloroform or ether, very slightly soluble in glacial acetic acid, almost insoluble in dilute mineral acids.
Chemical properties
Yellow crystalline powder. The temperature of 316 ° C (327 ° C), very slightly soluble in glacial acetic acid, almost insoluble in water, ethanol, chloroform. Odorless or almost odorless, tasteless.
Use
A weak diuretic. The effect is rapid and short-lived. Diuresis begins 2 hours after oral administration, peaks at 6 hours, and lasts for 8-12 hours. It is clinically used for refractory edema or ascites caused by heart failure, liver cirrhosis and chronic nephritis. It is also used for the production of hydrochlorothiazide or spironolactone. Case. This product has the effect of eliminating uric acid and is suitable for the treatment of gout.