Chemical Name:Ciprofloxacin hydrochloride

CAS No.: 86483-48-9

Molecular formula: C17H19ClFN3O3

Molecular weight: 367.8

Related categories: APIs; other reagents; Antimicrobial; API; Pharmaceutical intermediates; Feed additives; Pharmaceutical raw materials; Pharmaceutical raw materials; Veterinary raw materials; Antibacterial raw materials;

Chemical properties : White or yellowish crystalline powder. Melting point 255-257 ° C (decomposition).

Uses:

Broad-spectrum antibacterial drugs, suitable for heavy mixed infection, mainly used for chronic respiratory tract, E. coli, infectious rhinitis, avian cholera, avian typhoid, etc.

Production method:

3-chloro-4-fluoroaniline is diazotized and replaced to form 2,4-dichlorofluorobenzene, and then acetylated to obtain 2,4-dichloro-5-fluoroacetophenone, and Ethyl 2,4-dichloro-5-fluorobenzoylacetate was prepared by condensation of diethyl carbonate, and then reacted with triethyl orthoformate, acetic anhydride and cyclopropylamine to form 2-(3,4-dichloro). Ethyl 5-fluorobenzoyl)-3-cyclopropylaminoacrylate, which is reacted with NaH in anhydrous dioxane and refluxed for 2 h to give 1-cyclopropyl-7-chloro-6-fluoro-1 , 4-dihydro-4-oxoquinoline-3-carboxylic acid, and finally reacted with water piperazine to give cyclopropionic acid.